SEMAX SPRAY

Semax Spray 50mg

Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is a synthetic heptapeptide analog of the adrenocorticotropic hormone fragment ACTH(4-10), specifically incorporating the ACTH(4-7) core sequence with a stabilizing C-terminal Pro-Gly-Pro tripeptide. It has been studied in cellular biology, neurobiology, and biochemical research literature examining melanocortin receptor interactions, neurotrophic factor expression (including BDNF pathways), monoaminergic signaling, and neuroprotective mechanisms in experimental models.

Each bottle contains 50mg of Semax in a ready-to-use spray formulation within a sealed 30mL bottle delivering approximately 200 metered sprays, verified through Mile High Compounds’ three-tier quality protocol: 7x independent third-party analytical testing, 4-vial (or multi-unit) batch conformity verification, and comprehensive heavy metal screening.

Product Specifications

• Compound: Semax (Met-Glu-His-Phe-Pro-Gly-Pro)
• Class: Synthetic heptapeptide / ACTH(4-10) analog
• Sequence: Met-Glu-His-Phe-Pro-Gly-Pro
• Molecular Weight: ~813.9 Da
• Form: Ready-to-use aqueous spray solution
• Bottle Size: 50mg total in 30mL bottle (~200 sprays)
• Purity: 99%+ verified by HPLC and mass spectrometry (See COAs)

Research Background

Semax has been investigated in research literature across several scientific contexts:

• Melanocortin receptor and ACTH fragment research — studies examining receptor interactions and cellular signaling pathways involving the ACTH/α-MSH peptide family without corticotropic activity
• Neurotrophic factor pathway research — investigations into modulation of BDNF and related signaling in hippocampal and cortical models
• Monoaminergic system research — studies on dopaminergic and serotonergic parameters in rodent models
• Neuroprotective and cellular stress response research — examination of effects in experimental ischemia, oxidative stress, and gene expression models
• Short-chain peptide chemistry and structure-activity research — analytical and comparative studies on ACTH-derived peptides and stabilizing modifications

Semax is notable in research literature as a stabilized synthetic analog designed to retain the neuroactive properties of the ACTH(4-7) fragment while enhancing metabolic stability via the Pro-Gly-Pro extension. Foundational research is available through PubMed (pubmed.ncbi.nlm.nih.gov) and the National Institutes of Health’s PMC database (pmc.ncbi.nlm.nih.gov), where researchers can access peer-reviewed studies on Semax and related ACTH/melanocortin peptide research.

Analytical Verification

Every batch undergoes Mile High Compounds’ comprehensive analytical protocol:

• High-Performance Liquid Chromatography (HPLC) for purity quantification
• Mass Spectrometry (MS) for molecular weight and identity confirmation
• 14-day sterility testing
• Endotoxin analysis
• Multi-unit batch conformity verification — statistically robust consistency testing across each production batch, exceeding the industry-standard single-unit sampling approach
• Heavy metal screening for lead, arsenic, cadmium, mercury, and additional trace metals
• Container and seal integrity verification

Batch-specific Certificates of Analysis (COAs) accompany every order, documenting full testing results across all verification protocols.

Storage and Handling

• Storage: Cool, dry location away from direct light; refrigerate at 2-8°C for optimal stability
• Protect from light and excessive heat
• Avoid: Freezing or prolonged exposure to elevated temperatures to preserve compound stability and solution integrity
• Use within the labeled period after first opening for optimal research integrity

Quality Standards

Mile High Compounds maintains a rigorous quality control framework across all research compounds. Our multi-layered testing protocol provides researchers with verified, high-purity reference materials supported by complete analytical documentation.

• 7x independent third-party testing per batch
• Multi-unit batch conformity verification
• Heavy metal screening for trace contaminant analysis
• cGMP-compliant manufacturing
• Full analytical traceability
• Same-day shipping for orders placed before 3PM MST

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This product is supplied for in vitro laboratory research only and has not been evaluated by the U.S. Food and Drug Administration. By purchasing, the buyer confirms they are 21 or older, a qualified research professional or institution, and will not use this material for human consumption, veterinary use, or any in vivo application. Mile High Compounds assumes no liability for misuse or off-label application.

About Mile High Compounds

Colorado-based research compound supplier specializing in high-purity reference materials for laboratory applications. Every batch undergoes our three-tier quality protocol: 7x independent third-party analytical verification, multi-unit batch conformity testing, and comprehensive heavy metal screening — manufactured in cGMP-compliant facilities.

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